Frequently Asked Questions
Is the focus of this first study to identify gene associations to the disease first, and then once these are identified, to perhaps do separate studies to look at whether these track in relatives with ME?
Yes, genetic associations to ME/CFS will be looked at first. The next step is unlikely to be “tracking in families” because we expect there to be not one or two DNA differences, but rather dozens or hundreds of DNA differences that tilt the balance one way or another, changing someone’s risk of having ME/CFS. Having one DNA difference is unlikely to be sufficient to change that risk.
Instead, the second step – once the type of cell or metabolic process that is disrupted in ME/CFS has been identified – will be to chase down what immediate effect this root cause has on the body and then see whether it can be reversed.
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The largest ever DNA study of ME/CFS
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