We will apply a diagnostic algorithm (a very specific set of rules) to assess people according to well accepted diagnostic criteria: the Institute of Medicine 2015 or the 2003 Canadian Consensus criteria, but we will not be using the Oxford or NICE 2007 criteria. Given that people with M.E., M.E. organisations, and ME/CFS biomedical researchers all regard it as a defining symptom of the disease, Post-Exertional Malaise (PEM) will be a mandatory symptom.

We undertook an online survey and the majority of people supported this. These criteria were also agreed at the MRC/NIHR Workshop with researchers, patients and carers.

The largest ever DNA study of ME/CFS

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